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O-Desmethyl Gefitinib
Item number: Cay22365-1
O-Desmethyl gefitinib is the major metabolite of gefitinib (Cay-13166) in human plasma, formed by the cytochrome P450 isoform CYP2D6. It is an active metabolite that inhibits EGFR similarly to gefitinib in subcellular assays (IC50s = 36 and 22 nM, respectively) but is less active in whole cell assays (IC50s = 760...
| Keywords: | 4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol |
| Application: | Metabolite, EGFR inhibitor |
| CAS | 847949-49-9 |
| MW: | 432.9 D |
From 44.00€
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O-Desmethyl gefitinib
Item number: TGM-T16369-100mg
Description: O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity. Target: EGFR. Smiles: Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1....
| Application: | Metabolite, EGFR inhibitor |
| CAS | 847949-49-9 |
| MW: | 432.88 D |
From 48.00€
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