JX06 is an irreversible inhibitor of pyruvate dehydrogenase kinases (PDHKs, IC50s = 49, 101, and 313 nM for PDHK1, PDHK2, and PDHK3, respectively). It is selective for PDHK1-3 over PDHK4 (IC50 = >10 µM) and 322 other kinases at 10 µM but does inhibit FAK in a cell-free panel but not in a cell-based assay. JX06 (10...

Description: JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively. Target: Dehydrogenase, Apoptosis, PDK. Smiles: S=C(SSC(=S)N1CCOCC1)N1CCOCC1. References: Sun W , Xie Z , Liu Y , et al. JX06 Selectively Inhibits Pyruvate...