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Item number: Cay28759-1

GW843682X is a reversible, cell-permeable polo-like kinase (PLK) inhibitor. It selectively inhibits Plk1 and Plk3 (IC50s = 2.2 and 9.1 nM, respectively) over PDGFR1beta, VEGFR2, Aurora A, and Cdk2/cyclin A (IC50s = 160, 360, 4,800, and 7,600 nM, respectively), as well as over 30 other kinases, in a cell-free assay....

Keywords:	5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide
Application:	Cell-permeable PLK inhibitor
CAS	660868-91-7
MW:	477.5 D

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GW843682X

Item number: TGM-T15454-10mg

Description: GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM). Target: VEGFR, PLK, Aurora Kinase, PDGFR, CDK. Smiles: COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC. References: Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on...

Keywords:	GW843682
Application:	Cell-permeable PLK inhibitor
CAS	660868-91-7
MW:	477.46 D

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