MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of...

Selumetinib is a selective inhibitor of MEK1/2. Selumetinib treatment induced G1 cell-cycle arrest and apoptosis and suppression of tumor growth as xenografts in immunodeficient mice.

Description: Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1). Target: ERK, MEK, Apoptosis. Smiles:...

Appearance: White to off-white solid. Solubility: Soluble in DMSO (100mg/ml). Soluble in ethanol (~1mg/ml with warming). Insoluble in water. InChi Key: CYOHGALHFOKKQC-UHFFFAOYSA-N Smiles: Cn1cnc2c1cc(c(c2F)Nc3ccc(cc3Cl)Br)C(=O)NOCCO Selumetinib is an orally available, potent and selective ATP non-competitive...