Selumetinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with... more
Product information "Selumetinib"
Description: Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1). Target: ERK, MEK, Apoptosis. Smiles: CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3Cl)=C(C=C12)C(=O)NOCCO. References: Yeh TC, et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007 Mar 1,13(5):1576-83.
| Keywords: | AZD6244, ARRY-142886 |
| Supplier: | TargetMol |
| Supplier-Nr: | T6218 |
Properties
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| MW: | 457.68 D |
| Formula: | C17H15BrClFN4O3 |
Database Information
| CAS : | 606143-52-6| Matching products |
| KEGG ID : | K04368 | Matching products |
| Protein Atlas Nr. : | Phosphorylation (other) |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H317, H318, H361, H373, H411 |
| P Phrases: | P201, P202, P260, P261, P272, P273, P280, P310, P314, P321, P391, P302+P352, P305+P351+P338, P308+P313, P333+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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