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Item number: Cay22199-10

VU0357121 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that has an EC50 value of 33 nM for the rat receptor expressed in HEK293 cells in a calcium flux assay. It is selective for mGluR5 and does not modulate responses at mGluR2-4 or mGluR6-8 but does inhibit mGluR1.Formal Name:...

Keywords:	4-butoxy-N-(2,4-difluorophenyl)-benzamide
Application:	mGluR5 positive allosteric modulator
CAS	433967-28-3
MW:	305.3 D

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VU 0357121

Item number: TGM-T6725-100mg

Description: VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. Target: GluR. Smiles: CCCCOC1=CC=C(C=C1)C(=O)NC1=CC=C(F)C=C1F. References: Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716.

Application:	mGluR5 positive allosteric modulator
CAS	433967-28-3
MW:	305.32 D

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