VU0357121

VU0357121 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that has an EC50 value of 33 nM for the rat receptor expressed in HEK293 cells in a calcium flux assay. It is selective for mGluR5 and does not modulate responses at mGluR2-4 or mGluR6-8 but does inhibit mGluR1.Formal Name: 4-butoxy-N-(2,4-difluorophenyl)-benzamide. CAS Number: 433967-28-3. Molecular Formula: C17H17F2NO2. Formula Weight: 305.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 15 mg/ml. lambdamax: 262 nm. SMILES: FC1=CC(F)=C(NC(C2=CC=C(OCCCC)C=C2)=O)C=C1. InChi Code: InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21). InChi Key: AHCYOTLTLQTPSU-UHFFFAOYSA-N.