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Item number: Cay42399-10

An inhibitor of the Rho GEF 12-RhoA protein-protein interaction, binds to the DH-PH domain of Rho GEF 12 in a cell-free assay (Kd = 76 nM), inhibits serum-induced phosphorylation of MLC and FAK, a marker of RhoA activity, in NIH3T3 cells at 10 and 30 µM, inhibits cell growth, migration, invasion, and mammosphere...

Keywords:	4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
Application:	Rho GEF 12-RhoA protein-protein interaction inhibitor
CAS	429653-73-6
MW:	384.43 D

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Y16

Item number: TGM-T3553-100mg

Description: Y16 is a G-protein-coupled Rho GEFs inhibitor, works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling functions. Target: Rho, Ras. Smiles: Cc1cccc(COc2cccc(\C=C3/C(=O)NN(C3=O)c3ccccc3)c2)c1. References: Yoneda T,et al. The...

CAS	429653-73-6
MW:	384.43 D

From 30.00€ *

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