2 products were found matching "2832047-80-8"!

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Item number: Cay42127-1

A DNA polymerase theta inhibitor (IC50 = 0.55 nM), selective for DNA polymerase theta over DNA polymerase alpha, -epsilon, -gamma, and -nu (IC50s = >100 µM for all), inhibits double-strand break repair in AAVS1 loci in HCT116 cells (IC50 = 0.5 µM) and the proliferation of HCT116 BRCA2-/- cells (IC50 = 0.32 µM),...

Keywords:	N-[3-(6-amino-3-pyridazinyl)-2-propyn-1-yl]-N-(4-fluorophenyl)-3,5-bis(trifluoromethyl)-2-pyridineacetamide
Application:	DNA polymerase theta inhibitor
CAS	2832047-80-8
MW:	497.4 D

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RP-6685

Item number: TGM-T60187-100mg

Description: RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Poltheta), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Poltheta. In addition, it demonstrates significant antitumor efficacy as...

CAS	2832047-80-8
MW:	497.37 D

From 76.00€ *

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