RP-6685

Item number	Size	Delivery time	Price
TGM-T60187-1mg	1 mg	7 - 10 business days*	76.00€
TGM-T60187-5mg	5 mg	7 - 10 business days*	153.00€
TGM-T60187-1mL	1 ml	7 - 10 business days*	169.00€
TGM-T60187-10mg	10 mg	7 - 10 business days*	229.00€
TGM-T60187-25mg	25 mg	7 - 10 business days*	375.00€
TGM-T60187-50mg	50 mg	7 - 10 business days*	536.00€
TGM-T60187-100mg	100 mg	7 - 10 business days*	752.00€

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Description: RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Poltheta),... more

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Product information "RP-6685"

Description: RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Poltheta), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Poltheta. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1]. Target: DNA/RNA Synthesis. Smiles: Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1. References: Bubenik M, et al. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Poltheta. J Med Chem. 2022 Sep 20.

Supplier:	TargetMol
Supplier-Nr:	T60187

Properties

MW:	497.37 D
Formula:	C22H14F7N5O

Database Information

CAS :

2832047-80-8| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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