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TH-1760
Item number: Cay40469-10
TH-1760 is an inhibitor of nucleotide triphosphate diphosphatase NUDT15 (IC50 = 25 nM). It is selective for NUDT15 over a panel of additional Nudix family hydrolases and nucleotide pyrophosphatases at 100 µM, as well as a panel of 44 kinases at 10 µM. TH-1760 enhances thiopurine-induced cell death in NB4 and HL-60...
| Keywords: | 6-[[4-(1H-indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone |
| Application: | NUDT15 inhibitor |
| CAS | 2567914-01-4 |
| MW: | 426.4 D |
From 88.00€
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TH1760
Item number: TGM-T67864-100mg
Description: TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine. Target: NUDIX hydrolase. Smiles:...
| Keywords: | MKB |
| Application: | NUDT15 inhibitor |
| CAS | 2567914-01-4 |
| MW: | 426.45 D |
From 48.00€
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