Description: MF-094 is a potent and selective inhibitor of USP30 with an IC50 of 120 nM. Target: DUB. Smiles: CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)C3CCCCC3)cccc12. References: Kluge AF, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg...

MF094 is a ubiquitin-specific protease 30 (USP30) inhibitor (IC50 = 0.12 µM). It is selective for USP30 over 22 other USPs at 10 µM. MF094 (0.6, 1.7, and 5 µM) inhibits ubiquitinylated probe-induced active site modification of USP30 in mitochondria isolated from C2C12 myoblasts. It induces cell death in HSC-4 cells...