MF094

MF094 is a ubiquitin-specific protease 30 (USP30) inhibitor (IC50 = 0.12 µM). It is selective for USP30 over 22 other USPs at 10 µM. MF094 (0.6, 1.7, and 5 µM) inhibits ubiquitinylated probe-induced active site modification of USP30 in mitochondria isolated from C2C12 myoblasts. It induces cell death in HSC-4 cells when used at the concentrations of 0.2, 0.5, 1, and 2 µM. MF094 (1 mg/kg per day) reduces tumor growth in an SCC4 squamous cell carcinoma mouse xenograft model.Formal Name: alphaS-[(cyclohexylcarbonyl)amino]-N-[5-[[(1,1-dimethylethyl)amino]sulfonyl]-1-naphthalenyl]-benzenepropanamide. CAS Number: 2241025-68-1. Molecular Formula: C30H37N3O4S. Formula Weight: 535.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 210 nm. SMILES: CC(C)(C)NS(=O)(C1=CC=CC2=C1C=CC=C2NC([C@@H](NC(C3CCCCC3)=O)CC4=CC=CC=C4)=O)=O. InChi Code: InChI=1S/C30H37N3O4S/c1-30(2,3)33-38(36,37)27-19-11-16-23-24(27)17-10-18-25(23)31-29(35)26(20-21-12-6-4-7-13-21)32-28(34)22-14-8-5-9-15-22/h4,6-7,10-13,16-19,22,26,33H,5,8-9,14-15,20H2,1-3H3,(H,31,35)(H,32,34)/t26-/m0/s1. InChi Key: DQXORJHBZHLLTE-SANMLTNESA-N.