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Item number: TGM-T6798-100mg

Description: CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. Target: DNA Alkylation, DNA...

Keywords:	5-Aziridino-2,4-dinitrobenzamide, NSC 115829, CB1954
CAS	21919-05-1
MW:	252.18 D

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CB-1954

Item number: Cay21023-1

CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional...

Keywords:	NSC 115829, Tretazicar, 5-(1-aziridinyl)-2,4-dinitro-benzamide
Application:	Antitumor agent prodrug
CAS	21919-05-1
MW:	252.2 D

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