CB-1954

CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.Formal Name: 5-(1-aziridinyl)-2,4-dinitro-benzamide. CAS Number: 21919-05-1. Synonyms: NSC 115829, Tretazicar. Molecular Formula: C9H8N4O5. Formula Weight: 252.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 223, 269, 328 nm. SMILES: O=C(N)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(N2CC2)=C1. InChi Code: InChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14). InChi Key: WOCXQMCIOTUMJV-UHFFFAOYSA-N.