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Lomeguatrib
Item number: Cay11732-10
O6-Methylguanine-DNA methyltransferase (MGMT) (Cay-11176) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce...
| Keywords: | PaTrin 2, 6-[(4-bromo-2-thienyl)methoxy]-9H-purin-2-amine |
| Application: | MGMT inhibitor |
| CAS | 192441-08-0 |
| MW: | 326.2 D |
From 57.00€
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Lomeguatrib
Item number: TGM-T2495-5mg
Description: Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) . Target: DNA Alkylation, DNA Methyltransferase. Smiles: O(CC1=CC(Br)=CS1)C2=C3C(=NC(N)=N2)N=CN3. References: McElhinney RS, et al. J Med Chem, 1998, 41(26),...
| Keywords: | PaTrin-2 |
| Application: | MGMT inhibitor |
| CAS | 192441-08-0 |
| MW: | 326.17 D |
From 41.00€
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