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O6-Methylguanine-DNA methyltransferase (MGMT) (Cay-11176) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg.Formal Name: 6-[(4-bromo-2-thienyl)methoxy]-9H-purin-2-amine. CAS Number: 192441-08-0. Synonyms: PaTrin 2. Molecular Formula: C10H8BrN5OS. Formula Weight: 326.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml. lambdamax: 239, 284 nm. SMILES: BrC1=CSC(COC2=NC(N)=NC3=C2NC=N3)=C1. InChi Code: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16). InChi Key: JUJPKFNFCWJBCX-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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