Description: (5Z,2E)-CU-3 is a potent and highly selective inhibitor of the DGKalpha isozyme with an IC50 value of 0.6 µM, competing with ATP and exhibiting a Km value of 0.48 mM. It specifically targets the catalytic region of DGKalpha without affecting the regulatory region and has demonstrated antitumor and...

(5Z,2E)-CU-3 is an inhibitor of diacylglycerol kinase alpha (DGK-alpha, IC50 = 0.6 µM for the porcine enzyme). It is selective for DGK-alpha over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM). (5Z,2E)-CU-3 (5 µM) induces apoptosis in HeLa cervical and HepG2 liver cancer...