(5Z,2E)-CU-3

Description: (5Z,2E)-CU-3 is a potent and highly selective inhibitor of the DGKalpha isozyme with an IC50 value of 0.6 µM, competing with ATP and exhibiting a Km value of 0.48 mM. It specifically targets the catalytic region of DGKalpha without affecting the regulatory region and has demonstrated antitumor and immunogenic effects by promoting cancer cell apoptosis and T cell activation. Target: Apoptosis. Smiles: O=C1N(NS(=O)(=O)c2ccccc2)C(=S)S\C1=C/C=C/c1ccco1. References: Liu K, et al. A novel diacylglycerol kinase alpha-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar,57(3):368-79.