AZD 7986 is a reversible and covalent inhibitor of dipeptidyl peptidase 1 (DPP-1), also known as cathepsin C (IC50 = 3.9 nM). It is selective for DPP-1 over cathepsins S, -L, -B, -K, -D, -E, -Z, -H, and -G (IC50s = >20 µM for all), as well as a panel of greater than 200 enzymes, receptors, ion channels, and...

Description: Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively). Target: Proteasome. Smiles: Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1. References: Doyle K, et al. Discovery of Second...

Brensocatib, also known as AZD7986 is an oral DPPI (dipeptidyl peptidase 1, also known as cathepsin C) inhibitor. It is being studied for the treatment of bronchiectasis. Cathepsin C, also known as DPPI, is a lysosomal aspartic protease with dipeptidylpeptidase activity over a broad range of substrates. It is mostly...