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PX 12
Item number: Cay14192-1
PX 12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. As Trx1 is overexpressed in certain cancers, PX 12 is effective in suppressing the growth of cancer cells, with growth inhibition in a panel of 60 human tumors significantly correlated with expression...
| Keywords: | 2-[(1-methylpropyl)dithio]-1H-imidazole |
| Application: | Trx1 inhibitor |
| CAS | 141400-58-0 |
| MW: | 188.3 D |
From 51.00€
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PX-12
Item number: AG-CR1-3739-M005
White to off-white powder. Soluble in DMSO, ethanol or DMF (all 15mg/ml). Slightly soluble in water (~1mg/ml). Chemical. CAS: 141400-58-0. Formula: C7H12N2S2. MW: 188.3. PX-12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. High levels of Trx-1 have been...
| Keywords: | IV-2, 2-[(1-Methylpropyl)dithio]-1H-imidazole |
| Application: | Competitive, irreversible thioredoxin 1 (Trx1) inhibitor |
| CAS | 141400-58-0 |
| MW: | 188,3 D |
From 33.00€
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PX-12
Item number: TGM-T2283-100mg
Description: PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1alpha and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with...
| Keywords: | PX12, IV-2 |
| CAS | 141400-58-0 |
| MW: | 188.31 D |
From 45.00€
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