PX-12
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor... more
Product information "PX-12"
Description: PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1alpha and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival. Target: Thioredoxin. Smiles: CCC(C)SSc1ncc[nH]1. References: Welsh SJ, et al. Mol Cancer Ther. 2003, 2(3), 235-243.
| Keywords: | PX12, IV-2 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2283 |
Properties
| MW: | 188.31 D |
| Formula: | C7H12N2S2 |
Database Information
| CAS : | 141400-58-0| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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