Description: CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent...

CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively). It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS, IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell...