CB-1158

CB-1158 is an inhibitor of arginase I and II (IC50s = 0.086 and 0.296 µM for the human enzymes, respectively). It is selective for arginase I and II over neuronal nitric oxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS, IC50s = >50 µM for all). CB-1158 reverses inhibition of T cell proliferation induced by granulocytes in vitro (IC50 = 0.204 µM). It reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 100 mg/kg twice per day.Formal Name: alpha-amino-alpha-(4-boronobutyl)-1-[(2,4-dichlorophenyl)methyl]-4-piperidineacetic acid. CAS Number: 1345810-21-0. Synonyms: INCB 01158, Numidargistat. Molecular Formula: C18H27BCl2N2O4. Formula Weight: 417.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=CC(Cl)=C(CN2CCC(C(C(O)=O)(N)CCCCB(O)O)CC2)C=C1. InChi Code: InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25). InChi Key: ISYBHIALKUAHGV-UHFFFAOYSA-N.