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Item number: Cay11086-10

Apart from direct peroxisome proliferator-activated receptor gamma (PPARgamma) agonism, several PPARgamma ligands have recently been shown to exert anti-diabetic effects through a second, distinct biochemical function: blocking the obesity-linked phosphorylation of PPARgamma by cyclin-dependent kinase 5 (Cdk5) at...

Keywords:	4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid
Application:	Blocks phosphorylation of PPARgamma by Cdk5
CAS	1338259-05-4
MW:	547.6 D

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SR1664

Item number: TGM-T23389-100mg

Description: SR1664 is a potent and selective PPARgamma inhibitor with potential antidiabetic activity. SR1664 binds to PPARgamma and potently inhibits Cdk5-mediated PPARgamma phosphorylation (IC50 = 80 nM, Ki = 28.67 nM) without exhibiting PPARgamma agonist activity. Target: PPAR. Smiles:...

Keywords:	SR 1664
CAS	1338259-05-4
MW:	547.6 D

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