Description: MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential...

A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...