4 products were found matching "1260907-17-2"!
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I-BET762
Item number: Cay10676-1
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd =...
| Keywords: | GSK525762A, (S)-2-(6-(4-chlorophenyl)-8-methoxy-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide |
| Application: | BET protein studies |
| CAS | 1260907-17-2 |
| MW: | 423.9 D |
From 43.00€
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GSK-J1
Item number: SYN-3030-M100
GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other...
| Keywords: | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine |
| Application: | H3K27 histone demethylase JMJD3 (KDM6B) / UTX (KDM6A) inhibitor |
| CAS | 1260907-17-2 |
| MW: | 389.5 D |
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I-BET762
Item number: SYN-3033-M001
I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762...
| Keywords: | GSK-525762A |
| Application: | BET (bromodomain and extra terminal domain) protein BRD2 / BRD3 / BRD4 inhibitor |
| CAS | 1260907-17-2 |
| MW: | 423.9 D |
From 106.00€
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I-BET-762
Item number: LKT-I0518.1
BRD inhibitor.
| Keywords: | GSK525762 |
| Application: | BRD inhibitor |
| CAS | 1260907-17-2 |
| MW: | 423.9 D |
From 99.00€
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