GSK-J1

Item number	Size	Manual	SDS	Delivery time	Price
SYN-3030-M001	1 mg	-	-	3 - 9 business days*	79.00€
SYN-3030-M005	5 mg	-	-	3 - 9 business days*	119.00€
SYN-3030-M010	10 mg	-	-	3 - 9 business days*	198.00€
SYN-3030-M050	50 mg	-	-	3 - 9 business days*	724.00€
SYN-3030-M100	100 mg	-	-	3 - 9 business days*	-

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GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A),... more

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Product information "GSK-J1"

GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A), with IC50 values of 28nM and 53nM, respectively. GSK-J1 also has less potent inhibitory activity against KDM5B, KDM5C and KDM5A, with IC50 values of 170, 550 and 6,800nM, respectively. It shows no activity against other histone demethylases (IC50 >20µM), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30µM.

Keywords:	N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
Supplier:	SYNkinase
Supplier-Nr:	3030

Properties

Application:	H3K27 histone demethylase JMJD3 (KDM6B) / UTX (KDM6A) inhibitor
MW:	389.5 D
Formula:	C22H23N5O2
Purity:	>95%
Format:	Solid

Database Information

CAS :	1373422-53-7\| Matching products
KEGG ID :	K11448 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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