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Gimeracil
Item number: Cay16525-100
Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DYPD, Ki = 0.36 µM), the rate limiting enzyme in the catabolism of pyrimidines, including 5-fluorouracil (5-FU, Cay-14416). It inhibits the degradation of 5-FU in rat liver extracts (IC50 = 0.1 µM). Gimeracil inhibits homologous recombination and enhances...
| Keywords: | 5-Chlorodihydropyrimidine, CDHP, Gimestat, 5-chloro-4-hydroxy-2(1H)-pyridinone |
| Application: | Dihydropyrimidine dehydrogenase inhibitor |
| CAS | 103766-25-2 |
| MW: | 145.5 D |
From 58.00€
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Gimeracil
Item number: CDX-G0209-G001
White to yellow crystalline powder. Soluble in DMSO (25mg/ml) or DMF (20mg/ml). Chemical. CAS: 103766-25-2. Formula: C5H4ClNO2. MW: 145.54. Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the...
| Keywords: | 5-Chloro-4-hydroxy-2(1H)-pyridinone, 5-Chloro-2,4-dihydroxypyridine, 5-Chloro-4-hydroxy-2-pyridone, Gimestat, CDHP |
| CAS | 103766-25-2 |
| MW: | 145,54 D |
From 77.00€
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Gimeracil
Item number: TGM-T0987-100mg
Description: Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase. Target: Autophagy. Smiles: OC=1C(Cl)=CNC(=O)C1. References: Prescrire Int. 2013 May,22(138):122.
| Keywords: | Gimestat |
| CAS | 103766-25-2 |
| MW: | 145.54 D |
From 30.00€
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