Gimeracil
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| CDX-G0209-G001 | 1 g | - | - |
3 - 9 business days* |
77.00€
|
||
| CDX-G0209-G005 | 5 g | - | - |
3 - 9 business days* |
290.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
White to yellow crystalline powder. Soluble in DMSO (25mg/ml) or DMF (20mg/ml). Chemical. CAS:... more
Product information "Gimeracil"
White to yellow crystalline powder. Soluble in DMSO (25mg/ml) or DMF (20mg/ml). Chemical. CAS: 103766-25-2. Formula: C5H4ClNO2. MW: 145.54. Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the chemotherapeutic drug 5-fluorouracil (5FU). It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.
| Keywords: | 5-Chloro-4-hydroxy-2(1H)-pyridinone, 5-Chloro-2,4-dihydroxypyridine, 5-Chloro-4-hydroxy-2-pyridone, Gimestat, CDHP |
| Supplier: | Chemodex |
| Supplier-Nr: | G0209 |
Properties
| MW: | 145,54 D |
| Formula: | C5H4ClNO2 |
| Purity: | > 99% |
| Format: | Solid |
Database Information
| CAS : | 103766-25-2| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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