GDC-0980 is an inhibitor of PI3K and mTORC1/2 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. GDC-0980 inhibits cell growth in uterine serous carcinoma cells and decreases vascular density by altering vascular permeability parameter K (trans) in other cellular models. GDC-0980 inhibits cell...

GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kalpha, beta, delta, and gamma, respectively, in cell-free assays. It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases. GDC-0980 induces...

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC(50) values of 5, 27, 7, and 14nM for PI3Kalpha-delta respectively. It inhibits mTOR with a Ki of 17nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid

Description: Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kalpha(IC50=5 nM), PI3Kbeta(IC50=27 nM), PI3Kdelta(IC50=7 nM), PI3Kgamma (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal cell carcinoma, and endometrial carcinoma, among others. Target:...