WISP1/CCN4 Protein, Mouse, Recombinant (His)

WISP1/CCN4 Protein, Mouse, Recombinant (His)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-TMPK-00732-100ug	100 µg		-		7 - 10 business days*		439.00€
TGM-TMPK-00732-500ug	500 µg		-		7 - 10 business days*		1,754.00€

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Description: The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays... more

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Product information "WISP1/CCN4 Protein, Mouse, Recombinant (His)"

Description: The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin alpha6beta1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

Keywords:	WISP1c, WISP1tc, ELM-1, CCN4, WISP1i, WISP-1
Supplier:	TargetMol
Supplier-Nr:	TMPK-00732

Properties

Conjugate:	No
MW:	39.4 kD

Database Information

KEGG ID :	K22471 \| Matching products
UniProt ID :	O54775 \| Matching products
Gene ID :	GeneID 22402 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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