Toll-like receptor 1 (TLR1), partial, human, recombinant

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 25-580aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: SEFLVDRSKN GLIHVPKDLS QKTTILNISQ NYISELWTSD ILSLSKLRIL IISHNRIQYL DISVFKFNQE LEYLDLSHNK LVKISCHPTV NLKHLDLSFN AFDALPICKE FGNMSQLKFL GLSTTHLEKS SVLPIAHLNI SKVLLVLGET YGEKEDPEGL QDFNTESLHI VFPTNKEFHF ILDVSVKTVA NLELSNIKCV LEDNKCSYFL SILAKLQTNP KLSNLTLNNI ETTWNSFIRI LQLVWHTTVW YFSISNVKLQ GQLDFRDFDY SGTSLKALSI HQVVSDVFGF PQSYIYEIFS NMNIKNFTVS GTRMVHMLCP SKISPFLHLD FSNNLLTDTV FENCGHLTEL ETLILQMNQL KELSKIAEMT TQMKSLQQLD ISQNSVSYDE KKGDCSWTKS LLSLNMSSNI LTDTIFRCLP PRIKVLDLHS NKIKSIPKQV VKLEALQELN VAFNSLTDLP GCGSFSSLSV LIIDHNSVSH PSADFFQSCQ KMRSIKAGDN PFQCTCELGE FVKNIDQVSS EVLEGWPDSY KCDYPESYRG TLLKDFHMSE LSCNIT. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Reference: "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.Hum. Mutat. 32:643-652(2011). Function: nan