TGFbeta1 (mutant) (human):Fc (human) (rec.)

TGFbeta1 (mutant) (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-210TGFBM-C100 100 µg - -

3 - 9 business days*

484.00€
 
The extracellular domain of a mutant human TGFbeta1 is fused at the C-terminus to the Fc portion... more
Product information "TGFbeta1 (mutant) (human):Fc (human) (rec.)"
The extracellular domain of a mutant human TGFbeta1 is fused at the C-terminus to the Fc portion of human IgG4. Site-directed mutagenesis was used to change three cysteine codons into a serine codon that are located in the pro region of the TGF-beta precursor at amino acid positions 33, 223, and 225. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the TGFbeta1 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. TGF-beta1 (Transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-beta1 is encoded by the TGFB1 gene. TGF-beta1 was first identified in human platelets as a protein with a molecular mass of 25 kaD with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 aa) that was proteolytically processed to produce a mature peptide of 112 aa. TGF-beta1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-beta1.
Keywords: LAP, TGFB, TGFB1, TGF-beta-1, Latency-associated peptide, Transforming growth factor beta-1
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-210TGFBM

Properties

Application: Bioassays
Conjugate: No
Expressed in: Hamster cells
Origin: Human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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