Recombinant Human CYP2A6 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Thr171. End Site: Lys280. Coverage: 0.24. Isoelectric Point: 5. Core Sequence: TFFLSRTVSN VISSIVFGDR FDYKDKEFLS LLRMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFQL LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 91%, Rat - 91%, Pig - 90%, Cynomolgus monkey - 96%, Protein Function: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity [The Uniprot Consortium]