PIP4K2B (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-7665-L.20	20 µg		-	-	Request delivery time estimate		115.00€
ABS-PP-7665-L.100	100 µg		-	-	Request delivery time estimate		205.00€

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Protein function: Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate... more

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Product information "PIP4K2B (human), recombinant protein"

Protein function: Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). [The UniProt Consortium]

Keywords:	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Diphosphoinositide kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PI(5)P 4-kinase type II beta, PIP4KII-beta, PtdIns(5)P-4-k
Supplier:	Absea
Supplier-Nr:	PP-7665-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	47.5 kD
Format:	Lyophilized

Database Information

KEGG ID :	K00920 \| Matching products
UniProt ID :	P78356 \| Matching products
Gene ID :	GeneID 8396 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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