PAD2 (human recombinant)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10785-50 50 µg -

6 - 10 business days*

494.00€
 
Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the... more
Product information "PAD2 (human recombinant)"
Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PAD enzymes catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. All enzymes are cytosolic except for PAD4 which is localized in the nucleus. PAD2 is the most widely expressed member and also the most conserved across mammalian species, implying it is the ancestral homologue of the PADs. Overexpression of PAD2 results in myelin loss in a transgenic model, potentially linking PAD2 activity to multiple sclerosis. It has also been shown to modify vimentin and beta/gamma-actin, potentially aggravating the autoantigen response in rheumatoid arthritis. PAD2 may also play a role in transcriptional regulation, as it has been shown capable of citrullinating histones, particularly H3 during mammalian reproductive cycles, when it is transcriptionally activated in the nucleus. Synonyms: PADI2, PAD-H19, Peptidylarginine Deiminase 2, Protein Arginine Deiminase 2. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant N-terminal His-tagged enzyme isolated from a baculovirus overexpression system. MW: 77.32 kDa. Formulation: 50 mM HEPES, pH 8.0, with 200 mM NaCl, 1 mM DTT and 10% glycerol. Specific Activity: >500 U/mg. UniProt Accession #: Q9Y2J8.
Keywords: PADI2, PAD-H19, PAD-H19, KIAA0994, Peptidylarginine deiminase II, Peptidylarginine deiminase II, Protein-arginine deiminase type-2, Protein-arginine deiminase type-2, Protein-arginine deiminase type II, Protein-arginine deiminase type II
Supplier: Cayman Chemical
Supplier-Nr: 10785

Properties

Application: Enzyme activity
Conjugate: No
Purity: >90% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319
P Phrases: P264, P280, P302+352, P305+351+338, P321, P332+313, P337+313, P362+364
Caution
Our products are for laboratory research use only: Not for administration to humans!
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