Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10784-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Peptidyl arginine deiminase 1 (PAD1) is a calcium-dependent enzyme that catalyzes the conversion... more
Product information "PAD1 (human, recombinant)"
Peptidyl arginine deiminase 1 (PAD1) is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It exists as a monomer and is composed of a C-terminal catalytic domain and two N-terminal immunoglobulin-like (Ig-like) domains. PAD1 is primarily expressed in uterine and epidermal cells and generally localized in the cytosol. PAD1 citrullinates non-histone proteins, such as keratin, filaggrin, and MEK1, as well as histone H3 at arginine 2 (H3R2), H3R8, H3R17, and H4R3, to regulate epidermal cell progression and embryonic development. The catalytic activity of PAD1 is lost by deleting the first six N-terminal amino acids. Decreased Padi1 expression or PAD1 inhibition reduces citrullination of H3R2, H3R8, H3R17, and H4R3 and inhibits primary mouse embryo preimplantation development. PADI1 mRNA is overexpressed in tumor tissue from patients with triple-negative breast cancer (TNBC), and PAD1 promotes proliferation and epithelial-to-mesenchymal transition (EMT) in a variety of TNBC cell lines in vitro and in mouse xenograft models. Cayman's PAD1 (human, recombinant) protein can be used for enzyme activity assay and Western blot (WB) applications.Synonyms: PADI1, PDI1, Peptidylarginine Deiminase 1, Protein Arginine Deiminase 1. Purity: >95% estimated by SDS-PAGE. Source: Active recombinant human N-terminal His-tagged PAD1 expressed in E. coli. Amino Acids: 2-663 (full length). MW: 76.4 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, with 150 mM sodium chloride, 1 mM DTT, and 20% glycerol. UniProt Accession #: Q9ULC6.
Keywords: | PAD1, PADI1, Peptidylarginine deiminase I, Peptidylarginine deiminase I, Protein-arginine deiminase type-1, Protein-arginine deiminase type I, Protein-arginine deiminase type-1, Protein-arginine deiminase type I |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10784 |
Properties
Application: | Enzyme kinetics |
Conjugate: | No |
MW: | 76,4 kD |
Purity: | >95% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K01481 | Matching products |
UniProt ID : | Q9ULC6 | Matching products |
Gene ID | GeneID 29943 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed