NUDT1 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-11981-L.20	20 µg	-	-	-	Request delivery time estimate		115.00€
ABS-PP-11981-L.100	100 µg	-	-	-	Request delivery time estimate		205.00€

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Protein function: Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a... more

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Product information "NUDT1 (human), recombinant protein"

Protein function: Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8- oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. [The UniProt Consortium]

Keywords:	Oxidized purine nucleoside triphosphate hydrolase, 2-hydroxy-dATP diphosphatase, 7, 8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, Methylated purine nucleoside triphosphate hydrolase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, R
Supplier:	Absea
Supplier-Nr:	PP-11981-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	19.5 kD
Format:	Lyophilized

Database Information

KEGG ID :	K17816 \| Matching products
UniProt ID :	P36639 \| Matching products
Gene ID :	GeneID 4521 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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