Product information "NUCB2, Recombinant, Mouse (DNA-binding Protein NEFA, Nucleobindin-2, Nesfatin)"
Nucelobindin-2 (NUCB2, Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite. Sequence: Human NUCB2 (aa 25-420) is fused at the C-terminus to a His-tag, expressed in E. coli. Molecular Weight: ~55kD (SDS-PAGE), Endotoxin: <1EU/ug (LAL test, Lonza), Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the or