NUCB2 (mouse, rec.)

Human NUCB2 (amino acids 25-420) is fused at the C-terminus to a His-tag. Liquid. 0.2µm-filtered solution in PBS, pH 7.2. Nucelobindin-2 (NUCB2, Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite.