Human TRPC6-Strep full length protein-synthetic nanodisc

Item number	Size	Manual	SDS	Delivery time	Price
DIM-FLP120759.10	10 µg	-	-	7 - 16 business days*	1,162.00€
DIM-FLP120759.50	50 µg	-	-	7 - 16 business days*	5,680.00€
DIM-FLP120759.100	100 µg	-	-	7 - 16 business days*	10,327.00€

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The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane.... more

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Product information "Human TRPC6-Strep full length protein-synthetic nanodisc"

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]. Human TRPC6-Strep full length protein-synthetic nanodisc. Protein function: Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. [The UniProt Consortium]

Keywords:	TRP-6, TrpC6, Transient receptor protein 6, Short transient receptor potential channel 6
Supplier:	DIMA
Supplier-Nr:	FLP120759

Properties

Application:	Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization
Conjugate:	No
Host:	Human cells
Species reactivity:	human
MW:	106.3 kD
Format:	Lyophilized

Database Information

KEGG ID :	K04969 \| Matching products
UniProt ID :	Q9Y210 \| Matching products
Gene ID :	GeneID 7225 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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