42 products were found matching "K04969"!

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not...

Description: TRPC3/6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on...

Description: SAR7334 hydrochloride, a potent and specific inhibitor of TRPC6 (IC50 of 7.9 nM), effectively targets and inhibits the TRPC6 channel. Target: Others. Smiles: Cl.Cl.N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N. References: Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume...

BI-749327 is an inhibitor of transient receptor potential canonical 6 (TRPC6, IC50 = 13 nM for the mouse channel). It is selective for TRPC6 over TRPC3 and TRPC7 (IC50s = 1,100 and 550 nM, respectively, for the mouse channels). BI-749327 (100, 250, and 500 nM) inhibits TRPC6-mediated reporter gene expression in...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPC6. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TRPC6. Antigen Species: Human

Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 543-592aa. Protein Length: Partial. Tag Info: C-terminal hFc-tagged. Target Protein Sequence: ARFMAFWHAS KAQSIIDAND TLKDLTKVTL GDNVKYYNLA RIKWDPSDPQ. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological...

GSK1702934A is an activator of transient receptor potential canonical 3 (TRPC3) and TRPC6. It induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing the human channels (EC50s = 0.08 and 0.44 µM, respectively). GSK1702934A enhances contractility and induces...

SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM). It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 µM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also...

Larixyl acetate is a diterpenoid that has been found in Larix and has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities. It inhibits the activity of TRPC6 (IC50 = 0.58 µM) and is selective for TRPC6 over TRPC3 (IC50 = 6.83 µM), as well as over nine additional TRP channels at 10 µM....

Protein function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion,...

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 µM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of...