Human GLP1R (Arg24-Tyr145), recombinant (C-Fc)

Recombinant Human Glucagon-like Peptide 1 Receptor is produced by our Mammalian expression system and the target gene encoding Arg24-Tyr145 is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1. [The UniProt Consortium]