170 products were found matching "K04581"!

Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and rat GLP-1R (Rattus norvegicus Glucagon-like peptide 1 receptor, NM_012728.2). Activation of rat GLP-1R in these cells can be monitored by measuring...

A GLP-1 derivative, binds to GLP-1R in HEK293 cells expressing the human receptor (IC50 = 3.67 nM), enhances glucose-stimulated insulin secretion in isolated mouse pancreatic beta-cells at 30 and 90 nM, decreases non-fasting blood glucose levels in db/db mice (ED50 = 3.024 nmol/kg), reduces food and water intake and...

A peptide fragment of exendin-4. SMILES: NCC(NCC(N1[C@H](C(N[C@H](C(O)=O)CO)=O)CCC1)=O)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C12H20N4O6.C2HF3O2/c13-4-9(18)14-5-10(19)16-3-1-2-8(16)11(20)15-7(6-17)12(21)22,3-2(4,5)1(6)7/h7-8,17H,1-6,13H2,(H,14,18)(H,15,20)(H,21,22),(H,6,7)/t7-,8-,/m0./s1. InChi Key:...

A peptide fragment of exendin-4. SMILES: [H]NCC(NCC(N1CCC[C@H]1C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@H](C(N2CCC[C@H]2C(N3CCC[C@H]3C(N4CCC[C@H]4C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F. InChi Code:...

A GLP-1R agonist, induces cAMP production in HEK293 cells expressing human GLP-1R (EC50 = 1.14 nM), reduces blood glucose levels in human GLP1R knock-in mice (ED50 = 0.07 mg/kg). SMILES: O=C(C1=CC=C(N=C2CC3=C(F)C=C(C4=CC=CC(OCC5=C(F)C=C(C#N)C=C5)=N4)C(C)=C3)C(N2C[C@H]6OCC6)=C1)O. InChi Code:...

The GLP-2R/CRE Luciferase Reporter HEK293 Cell Line is a HEK293 cell line engineered to express Glucagon-like peptide 2 receptor (GLP-2R) (NM_004246.3). The construct was delivered by lentiviral transduction of CRE/CREB Luciferase Reporter HEK293 Cell Line (#60515), which express a firefly luciferase reporter driven...

Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R, EC50 = 6. pM in a reporter assay using BHK cells expressing the human receptor). It decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = 95%. Formulation (Request formulation change): A solid. Solubility: DMSO:...

Recombinant CHO-K1 cells stably overexpress human glucagon like peptide 1 receptor (GLP1R) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

Survodutide is a peptide agonist of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP production in CHO-K1 cells expressing human GCGR or GLP-1R (EC50s = 0.52 and 0.33 nM, respectively). In vivo, survodutide (30 and 100 nmol/kg) reduces food intake in wild-type but not...

The GLP1R, a GPCR, is found on pancreatic beta cells and brain neurons. It regulates blood sugar by enhancing insulin secretion. In humans, it is encoded by the gene GLP1R on chromosome 6. GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of...

Recombinant CHO-K1 cells stably overexpress human glucagon-like peptide-1 receptor (GLP1R) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

Synthetic. Soluble in aqueous solution (5% AcOH) (1mg/ml). Glucagon-like peptide-1 (GLP-1) receptor agonist. Antidiabetic agent against type 2 diabetes (T2D). Stimulates insulin and suppresses glucagon secretion in a glucose-dependent manner. Longer-acting alternative to liraglutide. Chemically similar to...