Human ENPP3, recombinant (N-6His)

Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase 3 is produced by our Mammalian expression system and the target gene encoding Leu48-Ile875 is expressed with a 6His tag at N-terminus. Protein function: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity (PubMed:11342463). [The UniProt Consortium]