HDAC5 (human, recombinant)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009379-1 1 each -

6 - 10 business days*

648.00€
 
Histone deacetylase 5 (HDAC) is a zinc-dependent metalloenzyme and class IIa HDAC. It is composed... more
Product information "HDAC5 (human, recombinant)"
Histone deacetylase 5 (HDAC) is a zinc-dependent metalloenzyme and class IIa HDAC. It is composed of an N-terminal regulatory domain, which contains a myocyte-specific enhancer factor 2 (MEF2) binding site, two 14-3-3 binding sites, and a nuclear localization signal, a catalytic domain, and a C-terminal domain that contains a nuclear export signal. HDAC5 shuttles between the cytoplasm and nucleus in a manner dependent on calcium/calmodulin-dependent protein kinase (CaMK) and 14-3-3 and is mainly expressed in the heart, but is also found in brain, breast, colon, and prostate tissues. It acts as a transcriptional corepressor and has many binding partners, including the transcriptional coactivator myocardin, which is involved in smooth muscle differentiation. Knockout of Hdac5 induces cardiac hypertrophy in mice and impairs spatial memory formation in a mouse model of Alzheimer's disease. Tumor levels of HDAC5 are increased in various cancer types. Cayman's HDAC5 (human, recombinant) protein can be used for enzyme activity assays.Synonyms: Histone Deacetylase 5. Formula Weight: 51.0. Purity: >90%. Source: Active recombinant human C-terminal His-tagged HDAC5 catalytic domain expressed in insect cells. Amino Acids: 656-1,122. MW: 51 kDa. Formulation: (Request formulation change), 45 mM Tris-HCl, pH 8.0, 124 mM sodium chloride, 2.4 mM potassium chloride, 225 imidazole, and 10% glycerol. UniProt Accession #: Q9UQL6.
Keywords: Histone Deacetylase 5
Supplier: Cayman Chemical
Supplier-Nr: 10009379

Properties

Application: Enzyme activity
Conjugate: No
MW: 51 D
Purity: >90%
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H361
P Phrases: P201, P202, P264, P270, P280, P321, P330, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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