CSF-1R/CD115 (human, recombinant)

Colony-stimulating factor 1 receptor (CSF-1R), also known as CD115, is a single-pass transmembrane protein encoded by CSF1R, previously known as the c-fms proto-oncogene, in humans. It is composed of a glycosylated extracellular domain containing ligand-binding and dimerization regions, a transmembrane domain, and an intracellular tyrosine kinase domain. CSF-1R is expressed in monocytes, macrophages, osteoclasts, and microglia, among other cell types. Upon binding by CSF-1R or IL-34, CSF-1R dimerizes and is autophosphorylated leading to ERK1/2, AMPK, Src/FAK, or Akt signaling. In this way, CSF-1R is involved in a wide variety of processes, including osteoclast cytoskeletal remodeling, macrophage motility, proliferation, and survival, and microglial proliferation. Increased intratumoral expression of CSF1R is associated with multiple cancer types and is predictive of poor prognosis in hematological cancers. Cayman's CSF-1R/CD115 (human, recombinant) protein can be used for binding assays. This protein consists of 493 amino acids and has a calculated molecular weight of 54. kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 100 kDa due to glycosylation.