144 products were found matching "K05090"!

ARRY-382 is an inhibitor of the colony-stimulating factor 1 receptor (CSF1R, IC50 = 9 nM). It is selective for CSF1R over PDGFR, c-Kit, and FMS-related tyrosine kinase 3 (FLT3, IC50s = >10,000 nM for all). ARRY-382 (10 µM) induces apoptosis in several primary human chronic lymphocytic leukemia (CLL) cell lines. It...

AZD 7507 is an inhibitor of CSF-1 receptor tyrosine kinase (FMS, IC50 = 3 nM). It is selective for FMS over c-KIT, aurora kinase 5 (ARK-5), FMS-related tyrosine kinase 4 (FLT4), p90 ribosomal S6 kinase (RSK1), and 77 other kinases at 1 µM. AZD 7505 (100 nM) induces apoptosis in isolated Fms+ mouse bone marrow cells...

Vimseltinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R, IC50 = 3.7 nM). It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), PDGFRalpha, PDGFRbeta, and KIT (IC50s = >3,300, 436, 2,300, and 476 nM, respectively). Vimseltinib inhibits the proliferation of M-NFS-60 leukemia cells...

Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of...

Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of...

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a...

CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a...

cFMS kinase is the cellular homolog of the v-FMS oncogene product of the Susan McDonough strain of the feline sarcoma virus. It can autophosphorlyate colony-stimulating factor (CSF-1), which promotes the survival, proliferation, and differentiation of mononuclear phagocytes. GW 2580 selectively inhibits cFMS kinase...

Seralutinib is an inhibitor of PDGFR, c-Kit, and colony stimulating factor 1 receptor (CSF1R). It inhibits PDGF-BB-induced phosphorylation of ERK in PDGFRalpha-dependent H1703 human lung epithelial cells, human pulmonary arterial smooth muscle cells (HPASMCs), which express PDGFRalpha and PDGFRbeta, and human lung...

PLX5622 is a brain-penetrant inhibitor of the colony stimulating factor 1 receptor (CSF1R, IC50 = 0.016 µM). It is selective for CSF1R over FMS-related tyrosine kinase 3 (FLT3), Kit, Aurora C, and kinase insert domain receptor (VEGFR2, IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively) and is greater than 100-fold...

Ki20227 is an inhibitor of macrophage colony stimulating factor 1 (CSF1) receptor tyrosine kinase (c-Fms, IC50 = 2 nM). It inhibits CSF1-dependent c-Fms phosphorylation in a dose-dependent manner in RAW264.7 cells and reduces CSF1-dependent growth of M-NFS-60 cells (IC50 = 14 nM). Ki20227 suppresses development of...

Soluble in DMSO at 40 mg/mL, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 20-100 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility