223 products were found matching "K05090"!
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Pexidartinib
Item number: Cay18271-5
Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3...
| Keywords: | PLX3397, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine |
| Application: | CSF1R antagonist, brain-penetrant CSF1R/c-Kit/FLT3 inhibitor |
| CAS | 1029044-16-3 |
| MW: | 417.8 D |
From 85.00€
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![Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]](https://www.biomol.com/media/image/7b/b5/bf/E-AB-F1107M1-50_200x200.jpg "Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]")
Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]
Item number: E-AB-F1107M1.100
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a...
| Keywords: | Anti-Csfmr, Anti-CD115, Anti-Csf1r, Anti-CSF-1R, Anti-M-CSF-R, Anti-CSF-1-R, EC=2.7.10.1, Anti-CSF-1 receptor,... |
| Application: | FC, FCM |
| Host: | Rat |
| Species reactivity: | mouse |
From 82.00€
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![Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]](https://www.biomol.com/media/image/e4/22/98/E-AB-F1107UM1-25_200x200.jpg "Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]")
Elab Fluor(R)700 Anti-Mouse CD115/CSF-1R Antibody[AFS98]
Item number: E-AB-F1107UM1.100
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a...
| Keywords: | Anti-Csfmr, Anti-CD115, Anti-Csf1r, Anti-CSF-1R, Anti-M-CSF-R, Anti-CSF-1-R, EC=2.7.10.1, Anti-CSF-1 receptor,... |
| Application: | FC, FCM |
| Host: | Rat |
| Species reactivity: | mouse |
From 101.00€
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AZD7507
Item number: TGM-T14380-100mg
Description: AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity. Target: HER, CSF-1R, Sodium Channel. Smiles: COc1cc2nnc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1N1CCN(CCO)CC1. References: Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the...
| Application: | FMS inhibitor |
| CAS | 1041852-85-0 |
| MW: | 454.5 D |
From 48.00€
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Edicotinib
Item number: TGM-T15199-100mg
Description: Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment. Target: FLT,...
| Keywords: | JNJ-527, JNJ-40346527 |
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1142363-52-7 |
| MW: | 461.6 D |
From 63.00€
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Pexidartinib
Item number: TGM-T2115-100mg
Description: Pexidartinib (PLX-3397) is a capsule containing a small-molecule receptor tyrosine kinase (RTK) inhibitor targeting KIT, CSF1R, and FLT3, with potential antineoplastic activity. Target: FLT, Apoptosis, c-Fms, CSF-1R, c-Kit. Smiles: FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1. References:...
| Keywords: | PLX-3397 |
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 1029044-16-3 |
| MW: | 417.81 D |
From 42.00€
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JNJ-28312141
Item number: TGM-T21330-25mg
Description: JNJ-28312141 is an orally active CSF1R inhibitor and a FLT3 inhibitor. JNJ-28312141 is a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Target: Others. Smiles:...
| Keywords: | JNJ 28312141, JNJ28312141 |
| Application: | CSF1R / FMS inhibitor |
| CAS | 885692-52-4 |
| MW: | 460.57 D |
From 1,520.00€
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ARRY-382
Item number: TGM-T35333-100mg
Description: ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM. Target: CSF-1R. Smiles: N(C(=O)C=1N2C(=NC1)C=C(OCCN3CCN(C)CC3)C=C2)C4=C5C(=NN(CC=6N=C(C)C=CC6)C5=CC=C4)C7CC7. References: David K Edwards V, et al. Oncotarget . 2018 May 15,9(37):24576-24589.
| Application: | CSF1R inhibitor |
| CAS | 1313407-95-2 |
| MW: | 564.68 D |
From 117.00€
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Ki20227
Item number: TGM-T4315-100mg
Description: Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRbeta(IC50: 451/217 nM), respectively. Target: c-Fms, CSF-1R, PDGFR, c-Kit, VEGFR. Smiles: COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1....
| Application: | CSF-1 receptor inhibitor |
| CAS | 623142-96-1 |
| MW: | 480.54 D |
From 40.00€
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Sotuletinib
Item number: TGM-T6119-100mg
Description: Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. Target: c-Fms, CSF-1R. Smiles: CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1. References: Pyonteck SM, et al. Nat Med. 2013,...
| Keywords: | BLZ945 |
| Application: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.48 D |
From 31.00€
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cFMS Receptor Inhibitor II
Item number: TGM-T5586-100mg
Description: cFMS Receptor Inhibitor II is a CSF1R kinase (FMS Receptor, colony stimulating factor 1 receptor, Macrophage colony-stimulating factor receptor) inhibitor with an IC50 of 2.8 nM, demonstrating significant selectivity over other kinases. This compound also exhibits notable CSF1R inhibition with an IC50...
| Application: | cFMS (CSF1R) inhibitor |
| CAS | 959860-85-6 |
| MW: | 368.43 D |
From 42.00€
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Pexidartinib hydrochloride
Item number: TGM-T62788-2mg
Description: Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM), with 10-100 times greater selectivity for these targets compared to FLT3 (IC50: 160 nM), KDR...
| Application: | Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115) |
| CAS | 2040295-03-0 |
| MW: | 454.28 D |
31.00€
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