CD278 [ICOS] (human) -muIg Fusion Protein, R-PE conjugated

CD278 [ICOS] (human) -muIg Fusion Protein, R-PE conjugated
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ANC-517-050 50 tests -

3 - 9 business days*

825.00€
 
A soluble fusion protein consisting of the extracellular (121aa) domain of mature human... more
Product information "CD278 [ICOS] (human) -muIg Fusion Protein, R-PE conjugated"
A soluble fusion protein consisting of the extracellular (121aa) domain of mature human CD278(ICOS) fused to murine IgG2a Fc (232 aa), with a predicted monomeric molecular weight of 40.4 kd. CD278-muIg binds to recombinant CD275(ICOSL, GL50)-muIg in EIA. The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology) and plays an analogous role in the T cell activation process. Each secondary signal from CD278 results in a discrete cytokine secretion profile displayed by the activated T cell. Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.
Keywords: ICOS, AILIM, CD278, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule
Supplier: Ancell
Supplier-Nr: 517-050

Properties

Application: ELISA, FC
Conjugate: Phycoerythrin
Expressed in: Hamster cells
Origin: Human
MW: 40 kD
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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